Indrani Chatterjee

My research interests are concerned with the molecular mechanisms of oocyte maturation, fertilization and development in the round worm Caenorhabditis elegans. As a postdoc, I am also studying the global genetic architecture that underlies early embryonic development using high-throughput genome wide RNA interference (RNAi). The genetic and molecular dissection of these events provides insights relevant to other important inter-cellular communication, ligand-receptor interactions and signal transduction mechanisms during the life and development of multicellular organisms.

My long term goal is to identify compounds from a chemical genomics screen that target pathways that increase embryonic lethality in C. elegans. The idea is to then use this information to treat infections caused by parasitic nematodes, which is a major global health problem.